Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …

Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …

The RD1 genomic region is present in virulent strains of Mycobacterium tuberculosis (MTB),
missing from the vaccine strain M. bovis BCG, and its importance to virulence has been …

Mycobacterium tuberculosis is an old enemy of the human race, with evidence of infection
observed as early as 5000 years ago. Although more host-restricted than Mycobacterium …

ESAT-6 is a small secreted protein of unknown function from Mycobacterium tuberculosis
that is of fundamental importance in virulence and protective immunity. A PSI-BLAST search …

Abstract Background The genome of Mycobacterium tuberculosis H37Rv has five copies of
a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 …