A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Histone methylation is critical for the formation and maintenance of long-term memories.
Long noncoding RNAs (lncRNAs) are regulators of histone methyltransferases and other …

Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

Abstract S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on
central nervous system function through cellular transmethylation pathways, including the …

An increasing number of studies show that an altered epigenetic landscape may cause
impairments in regulation of learning and memory-related genes within the aged …

Gene expression in the aging brain depends on transcription signals generated by
senescent physiology, interacting with genetic and epigenetic programs. In turn …

The integration of behavioral epigenetics' principles (eg, DNA methylation) into the study of
human infants' development has mainly focused on the effects of early adverse exposures …

Histone variants were recently discovered to regulate neural plasticity, with H2A. Z emerging
as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we …

Cognitive decline is a hallmark of the aging nervous system, characterized by increasing
memory loss and a deterioration of mental capacity, which in turn creates a favorable context …