Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L Xia, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

Challenges in the successful control of the avian coccidia

MW Shirley, AL Smith, DP Blake - Vaccine, 2007 - Elsevier
Eimeria species infect livestock in a host-specific manner and are the cause of the disease,
coccidiosis. Control of Eimeria species is essential and is currently dominated by …

A comprehensive evaluation of rodent malaria parasite genomes and gene expression

TD Otto, U Böhme, AP Jackson, M Hunt… - BMC biology, 2014 - Springer
Background Rodent malaria parasites (RMP) are used extensively as models of human
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA …

Disentangling genetic variation for resistance and tolerance to infectious diseases in animals

L Råberg, D Sim, AF Read - Science, 2007 - science.org
Hosts can in principle employ two different strategies to defend themselves against
parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation …

A systematic map of genetic variation in Plasmodium falciparum

C Kidgell, SK Volkman, J Daily, JO Borevitz… - PLoS …, 2006 - journals.plos.org
Discovering novel genes involved in immune evasion and drug resistance in the human
malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such …

Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model

AR Wargo, S Huijben, JC De Roode… - Proceedings of the …, 2007 - National Acad Sciences
Malaria infections frequently consist of mixtures of drug-resistant and drug-sensitive
parasites. If crowding occurs, where clonal population densities are suppressed by the …

Gene encoding a deubiquitinating enzyme is mutated in artesunate‐ and chloroquine‐resistant rodent malaria parasites§

P Hunt, A Afonso, A Creasey, R Culleton… - Molecular …, 2007 - Wiley Online Library
Artemisinin‐and artesunate‐resistant Plasmodium chabaudi mutants, AS‐ART and AS‐ATN,
were previously selected from chloroquine‐resistant clones AS‐30CQ and AS‐15CQ …

The role of immune-mediated apparent competition in genetically diverse malaria infections

L Råberg, JC De Roode, AS Bell… - The American …, 2006 - journals.uchicago.edu
Competitive interactions between coinfecting genotypes of the same pathogen can impose
selection on virulence, but the direction of this selection depends on the mechanisms behind …

Drug resistance genomics of the antimalarial drug artemisinin

EA Winzeler, MJ Manary - Genome biology, 2014 - Springer
Across the globe, over 200 million annual malaria infections result in up to 660,000 deaths,
77% of which occur in children under the age of five years. Although prevention is important …

Genetic mapping identifies novel highly protective antigens for an apicomplexan parasite

DP Blake, KJ Billington, SL Copestake… - PLoS …, 2011 - journals.plos.org
Apicomplexan parasites are responsible for a myriad of diseases in humans and livestock;
yet despite intensive effort, development of effective sub-unit vaccines remains a long-term …