Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

Copy number variation (CNV), where a segment of DNA differs in copy number between
different individuals, is an extensive and often underappreciated source of genetic variation …

Fcγ receptors are a family of cell–surface receptors that are expressed by a host of different
innate and adaptive immune cells, and mediate inflammatory responses by binding the Fc …

Natural killer (NK) cells are one of the main effector immune cells involved in antibody-
dependent cell-mediated cytotoxicity (ADCC). Upon recognition of cell-bound IgG …

The benefit of personalized medicine is that it allows the customization of drug therapy–
maximizing efficacy while avoiding side effects. Genetic polymorphisms are one of the major …

Background Recent advances in genomic technologies have facilitated genome-wide
investigation of human genetic variations. However, most efforts have focused on the major …

The rising incidence of obesity and type 2 diabetes is contributing to the escalating burden
of disease globally. These metabolic disorders are closely linked with diet and in particular …

Neutrophils are crucial components of the innate immunity. Differences exist in the
physiological, phenotypic, and functional characteristics between neonatal and adult …

Low FCGR3 copy numbers (CNs) has been associated with susceptibility to several
systemic autoimmune diseases. However, inconsistent associations were reported and …

Аннотация Геномная вариабельность является основой эволюции генома человека и
включает в себя вариации последовательности ДНК и структурную вариабельность. К …