Guidelines for accurate application of green and white analytical concepts: Merits vs demerits with insights of significant milestones of assessment tools applied for …

SS Saleh, RH Obaydo, MA El Hamd, Y Rostom… - Microchemical …, 2024 - Elsevier
In recent years, there has been a growing focus in analytical research on the ecological and
sustainable aspects of analytical methodologies. However, it is necessary to apply the …

A green method for the preparation of carbon quantum dots from yellow lupin peel waste for spectrofluorometric determination of nirmatrelvir

T Alomar, N AlMasoud, FR Mansour - Spectrochimica Acta Part A …, 2024 - Elsevier
The COVID-19 pandemic has highlighted the urgent need for effective antiviral agents. One
such promising drug is nirmatrelvir (NIRMA), which has demonstrated the ability to inhibit …

[HTML][HTML] Design of trio-colored validated HPLC method for synchronized multianalyte quantitation of four top selling antihyperlipidemic drugs in different fixed-dose …

HS Elbordiny, SM Elonsy, HG Daabees… - Green Analytical …, 2024 - Elsevier
The ongoing attempts to attain the sustainable development goals, to save the environment,
to embrace the novel paradigm of white analytical chemistry and to focus on the practicality …

Stability indicating RP-HPLC technique for simultaneous estimation of nirmatrelvir and ritonavir in their new copackaged dosage form for COVID-19 treatment

MG Yassin, A Roshdy, AA Marie - Scientific Reports, 2025 - nature.com
RP-HPLC technique was developed and optimized for simultaneous identification and
estimation of nirmatrelvir (NIR) and ritonavir (RIT) in their new copackaged tablet. Stability of …

Efficient integration of analytical quality-by-design and tri-hued HPLC-DAD approach for synchronized assessment of gemigliptin and rosuvastatin in their fixed-dose …

SM Mohyeldin, HG Daabees, W Talaat… - … Chemistry and Pharmacy, 2024 - Elsevier
Life-threatening atherosclerotic cardiovascular disorder is a well-recognized risk among
diabetics, which is clinically ascribed to their unbalanced plasma lipoproteins. Gemigliptin …

Hyphenating sustainability with chemometrics in chromatographic analysis of COVID combo therapy, nirmatrelvir and Molnupiravir, in presence of their overlapping …

SI Aboras, MA Korany, SA Ebied, RS Haggag… - … of Chromatography B, 2024 - Elsevier
Our manuscript managed to hyphenate the novelty and sustainability in one method. A novel
combination of molnupiravir (MNP) and nirmatrelvir (NTV) was found to be a potential …

Green and white-assessed validated chromatographic methods for Ondansetron purity testing in its pharmaceutical formulations; in silico toxicity profiling of impurities

CM El-Maraghy, MS Nour, HT ELbalkiny - Microchemical Journal, 2024 - Elsevier
Drug impurities are seen as a crucial threat to drug safety, specifically when dealing with
mutagenic/toxic impurities. Here, we present LC-MS/MS and HPTLC-densitometric methods …

Sustainable and technically smart spectrophotometric determination of PAXLOVID: a comprehensive ecological and analytical performance rating

SI Aboras, HM Maher, NZ Alzoman, HS Elbordiny - BMC chemistry, 2024 - Springer
Abstract The Food and Drug Administration (FDA) authorized the administration of ritonavir
(RIT)-boosted nirmatrelvir (NMV) on May 25, 2023, for the treatment of mild to moderate …

Development and comprehensive greenness assessment of HPLC method for quality control of β-sitosterol in pharmaceutical ointments with trio-color coded …

HI Aljohar, AM Al-Hossaini, SA Alzammay, S Alhabardi… - BMC chemistry, 2025 - Springer
A simple, rapid, and reproducible high-performance liquid chromatography (HPLC) method
has been developed and validated for the determination of β-sitosterol in the pharmaceutical …

Novel stability indicating HPLC method for the quantification of Nirmatrelvir in bulk drugs

P Ilayaraja, M Manivannan, P Parthiban - Microchemical Journal, 2024 - Elsevier
Nirmatrelvir is an antiviral drug that acts as a 3C-like protease inhibitor. It is used with the
combination of Ritonavir for the treatment of COVID-19. The World Health Organization …