K Davis, T Sheikh, N Aggarwal - Seminars in Diagnostic Pathology, 2023 - Elsevier
Tremendous strides have been made in the molecular and cytogenetic classification of acute lymphoblastic leukemia based on gene expression profiling data, leading to an …
TH Tran, S Langlois, C Meloche, M Caron… - Blood …, 2022 - ashpublications.org
The molecular hallmark of childhood acute lymphoblastic leukemia (ALL) is characterized by recurrent, prognostic genetic alterations, many of which are cryptic by conventional …
Philadelphia chromosome-like (Ph-like) ALL is a recent subtype of acute lymphoblastic leukemia. Although it does not express the BCR-ABL fusion gene, it has a behavior like true …
TH Tran, SK Tasian - Best Practice & Research Clinical Haematology, 2021 - Elsevier
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a subset of high-risk B-ALL associated with high relapse risk and inferior clinical outcomes across the …
Ruxolitinib (rux) Phase II clinical trials are underway for the treatment of high-risk JAK2- rearranged (JAK2 r) B-cell acute lymphoblastic leukemia (B-ALL). Treatment resistance to …
KM Park, EJ Yang, JM Lee, JO Hah… - Journal of Pediatric …, 2020 - journals.lww.com
Acute lymphoblastic leukemia (ALL) with hyperleukocytosis at diagnosis is associated with early morbidity and mortality due to complications of leukostasis. Of 535 pediatric ALL …
MZ Haider, F Anwer - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Philadelphia chromosome (Ph), named after the city where it was first described, was described for the first time by Nowell and Hungerford in 1960, in two patients who had lost …
L Maese, EA Raetz - Best Practice & Research Clinical Haematology, 2019 - Elsevier
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subset of B-cell ALL with a spectrum of underlying genetic alterations that activate kinase or …
Discussion The ZBTB20 protein is a member of the BTB (Broad complex, Tramtrack, Bric-a- brac)–ZF (zinc finger) family that acts primarily as transcriptional repressors and is involved …