Cells respond to viral infections through sensors that detect non-self-molecules, and through
effectors, which can have direct antiviral activities or adapt cell physiology to limit viral …

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it
is being explored for a variety of therapeutic applications. Many of these applications require …

The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides
the host with the ability to detect and respond to infection by viruses and other …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …

Poxviruses have evolved a wide array of mechanisms to evade the immune response, and
we provide an overview of the different immunomodulatory strategies. Poxviruses prevent …

Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …

ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …