As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we
reviewed the anti-inflammatory and pro-inflammatory effects of nicotine on inflammatory …

Production of inflammatory cytokines plays important roles in the response against tissue
injury and in host defense. Alterations in the production of inflammatory cytokines may cause …

Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions
such as Duchenne muscular dystrophy, where their use is associated with prolonged …

Duchenne muscular dystrophy (DMD) is a severe degenerative disorder caused by
mutations in the dystrophin gene. Dystrophin-deficient muscles are characterised by …

Macrophages are one of the top players when considering immune cells involved with tissue
homeostasis. Recently, increasing evidence has demonstrated that macrophages could also …

Background Muscle hypertrophy in the mdx mouse model of Duchenne muscular dystrophy
(DMD) can partially compensate for the loss of dystrophin by maintaining peak force …

Previous investigations have demonstrated the anti-inflammatory effects of cholinergic
agonists, such as nicotine. In the present study, we investigated the potential anti …

Cigarette smoking causes insulin resistance. However, nicotine induces anti-inflammation
and improves glucose tolerance in insulin-resistant animal models. Here, we determined the …

Smoking is associated with increased risk and poorer prognosis of pancreatic ductal
adenocarcinoma (PDAC). Nicotine acts through cholinergic nicotinic receptors, preferentially …

Our previous finding that the muscle nicotinic acetylcholine receptor (nAChR) and the Na, K-
ATPase interact as a regulatory complex to modulate Na, K-ATPase activity suggested that …