▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

In response to DNA damage, cells engage a complex set of events that together comprise
the DNA-damage response (DDR). These events bring about the repair of the damage and …

Telomeres protect chromosome ends from being detected as lesions and from triggering
DNA damage checkpoints. Paradoxically, telomere function depends on checkpoint proteins …

The germ line is an immortal cell lineage that is passed indefinitely from one generation to
the next. To identify the genes that are required for germline immortality, we isolated …

Background: The inability to efficiently repair DNA damage or remove cells with severely
damaged genomes has been linked to several human cancers. Studies in yeasts and …

In the yeast Saccharomyces cerevisiae, chromosomes terminate with a repetitive sequence
[poly (TG1–3)] 350 to 500 bp in length. Strains with a mutation of TEL1, a homolog of the …

The ends of eukaryotic chromosomes have long been defined as structures that must avoid
being detected as DNA breaks. They are protected from checkpoints, homologous …

Telomeres, found at chromosomal ends, are essential for stable maintenance of linear
chromosomes in eukaryotes. The ATM family of genes, including budding yeast TEL1 (Refs …

Hus1 is one of six checkpoint Rad proteins required for allSchizosaccharomyces pombe
DNA integrity checkpoints. MYC-tagged Hus1 reveals four discrete forms. The main form …

During the meiotic cell cycle, a surveillance mechanism called the “pachytene checkpoint”
ensures proper chromosome segregation by preventing meiotic progression when …