Adult tissues set the scene for a continuous battle between cells, where a comparison of
cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named …

Background Colorectal cancer liver metastases (CRCLM) are associated with a poor
prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti …

Simple Summary Liver metastases occur in almost half of patients with colorectal cancer,
either at the time of presentation (synchronous) or eventually as a metachronous recurrence …

Background The immune landscape of uveal melanoma liver metastases (UMLM) has not
been sufficiently studied. Methods Immune cell infiltrates (ICIs), PD-1 and PD-L1 were …

A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its
origin remains unclear. Here, we systematically quantify the capsule's extent and cellular …

Purpose: We describe the fibrotic rim formed in the desmoplastic histopathologic growth
pattern (DHGP) of colorectal cancer liver metastasis (CLM) using in situ sequencing (ISS) …

Objectives Almost half of all patients diagnosed with uveal melanoma will die of metastatic
disease. This has been attributed to early seeding of micrometastases. We investigate the …

Despite extensive research and improvements in understanding colorectal cancer (CRC), its
metastatic form continues to pose a substantial challenge, primarily owing to limited …

The replacement histopathologic growth pattern (rHGP) in melanoma liver metastases
connotes an aggressive phenotype (vascular co-option; angiotropic extravascular migratory …

There are several types of microvasculature supplying neoplasms:“newly formed blood
vessels”(neoangiogenesis), which are a component of the tumor microenvironment (TME) of …