As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

INTRODUCTION The global scale and rapid spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pose unprecedented challenges to society, health care …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

The NLRP3 inflammasome is activated by a wide range of stimuli and drives diverse
inflammatory diseases. The decrease of intracellular K+ concentration is a minimal upstream …

SARS-CoV-2 Omicron rapidly outcompeted other variants and currently dominates the
COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be …

Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …