Molecular photoswitches in aqueous environments

J Volarić, W Szymanski, NA Simeth… - Chemical Society …, 2021 - pubs.rsc.org
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Polymers for cytosolic protein delivery

J Lv, Q Fan, H Wang, Y Cheng - Biomaterials, 2019 - Elsevier
Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Rational design of poly (disulfide) s as a universal platform for delivery of CRISPR-Cas9 machineries toward therapeutic genome editing

J Guo, T Wan, B Li, Q Pan, H Xin, Y Qiu… - ACS Central …, 2021 - ACS Publications
We synthesized a series of poly (disulfide) s by ring-opening polymerization and
demonstrated that the copolymerization of monomer 1 containing diethylenetriamine …

High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder

Q Wang, JL Mynar, M Yoshida, E Lee, M Lee, K Okuro… - Nature, 2010 - nature.com
With the world's focus on reducing our dependency on fossil-fuel energy, the scientific
community can investigate new plastic materials that are much less dependent on petroleum …

Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications

H Lu, J Wang, Z Song, L Yin, Y Zhang… - Chemical …, 2014 - pubs.rsc.org
Polypeptides are fascinating materials with unique properties for various biological
materials. We highlight here recent advances in amino acid N-carboxyanhydrides (NCAs) …

Rational design of a polymer with robust efficacy for intracellular protein and peptide delivery

H Chang, J Lv, X Gao, X Wang, H Wang, H Chen… - Nano …, 2017 - ACS Publications
The efficient delivery of biopharmaceutical drugs such as proteins and peptides into the
cytosol of target cells poses substantial challenges owing to their large size and …

Dendrimers derived from 1→ 3 branching motifs

GR Newkome, C Shreiner - Chemical reviews, 2010 - ACS Publications
In 2008, we overviewed1 poly (amido amine) s, polypropylenimines, and related dendrimers
and dendrons possessing diverse 1 f 2 branching patterns that were predominately made …

Engineering the surface of smart nanocarriers using a pH‐/thermal‐/GSH‐responsive polymer zipper for precise tumor targeting therapy in vivo

P Zhang, Y Wang, J Lian, Q Shen, C Wang… - Advanced …, 2017 - Wiley Online Library
Nanocarrier surface chemistry plays a vital role in mediating cell internalization and
enhancing delivery efficiency during in vivo chemotherapy. Inspired by the ability of proteins …

Guanidinium-based “molecular glues” for modulation of biomolecular functions

R Mogaki, PK Hashim, K Okuro, T Aida - Chemical Society Reviews, 2017 - pubs.rsc.org
Molecular adhesion based on multivalent interactions plays essential roles in various
biological processes. Hence,“molecular glues” that can adhere to biomolecules may …