According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Nowadays, mass spectrometry‐based proteomics is carried out primarily in a bottom‐up
fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the …

This paper describes an open-source system for analyzing, storing, and validating
proteomics information derived from tandem mass spectrometry. It is based on a …

Mass spectrometry–based quantitative proteomics has become an important component of
biological and clinical research. Although such analyses typically assume that a protein's …

Mass spectrometry-based multiple reaction monitoring (MRM) quantitation of proteins can
dramatically impact the discovery and quantitation of biomarkers via rapid, targeted …

Tandem mass spectrometry-based shotgun proteomics has become a widespread
technology for analyzing complex protein mixtures. A number of database searching …

Integral membrane proteins (IMPs) lie at the critical junctions between intracellular
compartments and cells and their environment. As such, IMPs are in a unique position to …

A system for creating a library of tandem mass spectra annotated with corresponding
peptide sequences was described. This system was based on the annotated spectra …

A highly‐multiplexed MRM‐based assay for determination of cardiovascular disease (CVD)
status and disease classification has been developed for clinical research. A high‐flow …

MS-based proteomics usually involves the fragmentation of tryptic peptides (tandem MS or
MS2) and their identification by searching protein sequence databases. In ion trap …