Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We acquired a rapidly preserved human surgical sample from the temporal lobe of the
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment
for action potential generation, under GABAergic control by the" chandelier" or axo-axonic …

Learning from experience depends at least in part on changes in neuronal connections. We
present the largest map of connectivity to date between cortical neurons of a defined type …

On the timescale of sensory processing, neuronal networks have relatively fixed anatomical
connectivity, while functional interactions between neurons can vary depending on the …

The posterior parietal cortex exhibits choice-selective activity during perceptual decision-
making tasks,,,,,,,,–. However, it is not known how this selective activity arises from the …

We present an auxiliary learning task for the problem of neuron segmentation in electron
microscopy volumes. The auxiliary task consists of the prediction of local shape descriptors …