Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Small bioactive peptides for biomaterials design and therapeutics

IW Hamley - Chemical reviews, 2017 - ACS Publications
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …

Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery

B Kim, JH Park, MJ Sailor - Advanced materials, 2019 - Wiley Online Library
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides

S Dissanayake, WA Denny, S Gamage… - Journal of Controlled …, 2017 - Elsevier
Efficient intracellular trafficking and targeted delivery to the site of action are essential to
overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) …

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

KN Sugahara, T Teesalu, PP Karmali, VR Kotamraju… - science, 2010 - science.org
Poor penetration of anticancer drugs into tumors can be an important factor limiting their
efficacy. We studied mouse tumor models to show that a previously characterized tumor …

Tissue-penetrating delivery of compounds and nanoparticles into tumors

KN Sugahara, T Teesalu, PP Karmali, VR Kotamraju… - Cancer cell, 2009 - cell.com
Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a
strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that …

Targeting of drugs and nanoparticles to tumors

E Ruoslahti, SN Bhatia, MJ Sailor - Journal of cell biology, 2010 - rupress.org
The various types of cells that comprise the tumor mass all carry molecular markers that are
not expressed or are expressed at much lower levels in normal cells. These differentially …

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

T Teesalu, KN Sugahara… - Proceedings of the …, 2009 - National Acad Sciences
Screening of phage libraries expressing random peptides for binding to prostate cancer
cells primarily yielded peptides that had a C-terminal arginine (or rarely lysine) residue …

Peptides as targeting elements and tissue penetration devices for nanoparticles

E Ruoslahti - Advanced materials, 2012 - Wiley Online Library
The use of nanoparticles in medicine (nanomedicine) has recently become an intensely
studied field. Nanoparticles carrying drugs and imaging agents have already reached the …

Recombinant antibodies by phage display for bioanalytical applications

OI Guliy, SS Evstigneeva, LA Dykman - Biosensors and Bioelectronics, 2023 - Elsevier
Antibody phage display, aimed at preparing antibodies to defined antigens, is a useful
replacement for hybridoma technology. The phage system replaces all work stages that …