Portrait of the PI3K/AKT pathway in colorectal cancer

SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

[HTML][HTML] MiRNA as potential biomarkers and therapeutic targets for gastric cancer

VY Shin, KM Chu - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Gastric cancer is one of the leading causes of cancer mortality in the world. Aberrant
expression of microRNAs (miRNAs) is the hallmark of this disease. MiRNAs are …

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

P Shah, JV Fritz, E Glaab, MS Desai… - Nature …, 2016 - nature.com
Abstract Changes in the human gastrointestinal microbiome are associated with several
diseases. To infer causality, experiments in representative models are essential, but widely …

Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation

K Sugimachi, T Matsumura, H Hirata, R Uchi… - British journal of …, 2015 - nature.com
Background Predictive biomarkers for the recurrence of hepatocellular carcinoma (HCC)
have great benefit in the selection of treatment options, including liver transplantation (LT) …

[PDF][PDF] Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR‐125a‐5p and MiR‐125b

JK Kim, JH Noh, KH Jung, JW Eun, HJ Bae… - …, 2013 - Wiley Online Library
Sirtuins are nicotinamide adenine dinucleotide oxidized form (NAD+)‐dependent
deacetylases and function in cellular metabolism, stress resistance, and aging. For sirtuin7 …

TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2

Y Shuai, Z Ma, W Liu, T Yu, C Yan, H Jiang, S Tian… - Molecular cancer, 2020 - Springer
Background Gastric cancer (GC) is the third leading cause of cancer-related mortality
globally. Long noncoding RNAs (lncRNAs) are dysregulated in obvious malignancies …

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer

M Hu, S Zhu, S Xiong, X Xue… - Oncology reports, 2019 - spandidos-publications.com
Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …

Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes

S Kurozumi, Y Yamaguchi, M Kurosumi… - Journal of human …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes
at the post-transcriptional phase. miRNAs are considered to have roles in the development …

MicroRNA-148a Suppresses Tumor Cell Invasion and Metastasis by Downregulating ROCK1 in Gastric Cancer

B Zheng, L Liang, C Wang, S Huang, X Cao, R Zha… - Clinical Cancer …, 2011 - AACR
Purpose: MicroRNAs (miRNA) have been documented playing a critical role in cancer
development and progression. In this study, we investigate the role of miR-148a in gastric …

Molecular and circulating biomarkers of gastric cancer

W Jelski, B Mroczko - International Journal of Molecular Sciences, 2022 - mdpi.com
Gastric cancer (GC)—a common tumor that affects humans worldwide—is highly malignant
with a poor prognosis. GC is frequently not diagnosed until a relatively advanced stage …