Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Decorin as a multivalent therapeutic agent against cancer
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …
Decoding the matrix: instructive roles of proteoglycan receptors
The extracellular matrix is a dynamic repository harboring instructive cues that embody
substantial regulatory dominance over many evolutionarily conserved intracellular activities …
substantial regulatory dominance over many evolutionarily conserved intracellular activities …
MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor
K Shen, Q Liang, K Xu, D Cui, L Jiang, P Yin… - Biochemical …, 2012 - Elsevier
MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are
involved in tumor metastasis. In this study, we describe the down-regulation and function of …
involved in tumor metastasis. In this study, we describe the down-regulation and function of …
Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling
RV Iozzo, S Buraschi, M Genua, SQ Xu… - Journal of Biological …, 2011 - ASBMB
We have recently discovered that the insulin-like growth factor receptor I (IGF-IR) is up-
regulated in human invasive bladder cancer and promotes migration and invasion of …
regulated in human invasive bladder cancer and promotes migration and invasion of …
Caloric restriction augments radiation efficacy in breast cancer
A Saleh, B Simone, J Palazzo, JE Savage, Y Sano… - Cell cycle, 2013 - Taylor & Francis
Dietary modification such as caloric restriction (CR) has been shown to decrease tumor
initiation and progression. We sought to determine if nutrient restriction could be used as a …
initiation and progression. We sought to determine if nutrient restriction could be used as a …
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways
Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene
family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity …
family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity …
ATM mutations benefit bladder cancer patients treated with immune checkpoint inhibitors by acting on the tumor immune microenvironment
Immune checkpoint inhibitors (ICIs) have shown promising results in bladder cancer (BC).
However, only some patients respond to ICIs. DNA repair defects (DDR) play an important …
However, only some patients respond to ICIs. DNA repair defects (DDR) play an important …
Significance of talin in cancer progression and metastasis
A Desiniotis, N Kyprianou - International review of cell and molecular …, 2011 - Elsevier
Upon detachment from the extracellular matrix, tumor epithelial cells and tumor-associated
endothelial cells are capable of overcoming anoikis, gain survival benefits, and hence …
endothelial cells are capable of overcoming anoikis, gain survival benefits, and hence …
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A
A Morcavallo, M Genua, A Palummo… - Journal of Biological …, 2012 - ASBMB
The insulin receptor isoform A (IR-A) binds both insulin and insulin-like growth factor (IGF)-II,
although the affinity for IGF-II is 3–10-fold lower than insulin depending on a cell and tissue …
although the affinity for IGF-II is 3–10-fold lower than insulin depending on a cell and tissue …