An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Physical endurance and energy conservation are essential for survival in the wild. However,
it remains unknown whether and how meal timing regulates physical endurance and muscle …

The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …

Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase primarily located in
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …

Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

The process of tissue regeneration occurs in a developmentally timed manner, yet the role of
circadian timing is not understood. Here, we identify a role for the adult muscle stem cell …

Each individual has a unique gut microbiota; therefore, the genes in our microbiome
outnumber the genes in our genome by about 150 to 1. Perturbation in host nutritional status …

Sirtuin 5 (SIRT5) is a predominantly mitochondrial enzyme catalyzing the removal of glutaryl,
succinyl, malonyl, and acetyl groups from lysine residues through a NAD+-dependent …

Chondrosarcomas represent the second most common primary bone malignancy. Despite
the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) …