Constitutive heterochromatin formation and transcription in mammals
N Saksouk, E Simboeck, J Déjardin - Epigenetics & chromatin, 2015 - Springer
Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …
believed to ensure a condensed and transcriptionally inert chromatin conformation …
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …
prevalent post-translational modification and as an important regulator of cellular signal …
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
SE Polo, SP Jackson - Genes & development, 2011 - genesdev.cshlp.org
Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
The functional diversity of protein lysine methylation
S Lanouette, V Mongeon, D Figeys… - Molecular systems …, 2014 - embopress.org
Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
Histone post-translational modifications impact many aspects of chromatin and nuclear
function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating …
function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating …
The role of DNA methylation and histone modifications in transcriptional regulation in humans
JL Miller, PA Grant - Epigenetics: Development and Disease, 2012 - Springer
Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …
the completion and availability of the human genome sequence, transcriptional regulation …
Lysine methylation: beyond histones
Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …
Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice
A Gupta, CR Hunt, S Chakraborty… - Radiation …, 2014 - meridian.allenpress.com
The p53-binding protein 1 (53BP1) is a well-known DNA damage response (DDR) factor,
which is recruited to nuclear structures at the site of DNA damage and forms readily …
which is recruited to nuclear structures at the site of DNA damage and forms readily …
Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin
S Pellegrino, J Michelena, F Teloni, R Imhof… - Cell reports, 2017 - cell.com
The bivalent histone modification reader 53BP1 accumulates around DNA double-strand
breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end …
breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end …