Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in
refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue …

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Anticancer drugs resistance is a complex process that arises from altering in the drug
targets. Advances in the DNA microarray, proteomics technology and the development of …

Many approaches to cancer management are often ineffective due to adverse reactions,
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …

Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa
L. It has been shown that curcumin has a variety of pharmacological effects such as …

Introduction Multi-drug resistance (MDR) is a hindrance toward the successful treatment of
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Cancer is a devastating disease and is the second leading cause of death worldwide.
Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for …

ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in
cholesterol homeostasis, transport of various molecules in and out of cells and organelles …