Rodent models of post-traumatic stress disorder: behavioral assessment
Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …
biologically preserved behavioral and neurobiological responses to valent stimuli which …
The paraventricular nucleus of the thalamus as an integrating and relay node in the brain anxiety network
GJ Kirouac - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
The brain anxiety network is composed of a number of interconnected cortical regions that
detect threats and execute appropriate defensive responses via projections to the shell of …
detect threats and execute appropriate defensive responses via projections to the shell of …
Dynamic DNA methylation programs persistent adverse effects of early-life stress
C Murgatroyd, AV Patchev, Y Wu, V Micale… - Nature …, 2009 - nature.com
Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …
Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes, and future challenges in improving translation
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …
The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research
Translational research on post-traumatic stress disorder (PTSD) has produced limited
improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal …
improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal …
Animal models of social avoidance and social fear
I Toth, ID Neumann - Cell and tissue research, 2013 - Springer
Social fear and avoidance of social situations represent the main behavioral symptoms of
social anxiety disorder (SAD), a highly prevalent anxiety disorder that is poorly elucidated …
social anxiety disorder (SAD), a highly prevalent anxiety disorder that is poorly elucidated …
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
“Labels Matter: Is it stress or is it Trauma?”
G Richter-Levin, C Sandi - Translational Psychiatry, 2021 - nature.com
In neuroscience, the term 'Stress' has a negative connotation because of its potential to
trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more …
trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more …
Single prolonged stress: toward an animal model of posttraumatic stress disorder
S Yamamoto, S Morinobu, S Takei… - Depression and …, 2009 - Wiley Online Library
Although selective serotonin reuptake inhibitors (SSRIs) are reported to be effective in
decreasing posttraumatic stress disorder (PTSD) symptoms, a subgroup of PTSD patients …
decreasing posttraumatic stress disorder (PTSD) symptoms, a subgroup of PTSD patients …
Substrains matter in phenotyping of C57BL/6 mice
K Mekada, A Yoshiki - Experimental animals, 2021 - jstage.jst.go.jp
The inbred mouse strain C57BL/6 has been widely used as a background strain for
spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged …
spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged …