Chronic lung diseases include a variety of obstinate and fatal diseases, including asthma,
chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), idiopathic pulmonary …

Elafin and secretory leukocyte protease inhibitor (SLPI) are pleiotropic molecules chiefly
synthesized at the mucosal surface that have a fundamental role in the surveillance against …

Gene therapy has emerged as an alternative for the treatment of diseases refractory to
conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly …

Since CRISPR/Cas9 was harnessed to edit DNA, the field of gene therapy has witnessed
great advances in gene editing. New avenues were created for the treatment of diseases …

In this study lactoferrin (Lf) was investigated as a targeting ligand for receptor-mediated
gene delivery to human bronchial epithelial cells. A high number of lactoferrin receptors …

Nonviral gene delivery is now considered a promising alternative to viral vectors. Among
nonviral gene delivery agents, polyethylenimine (PEI) has emerged as a potent candidate …

Advances in biotechnology have led to an accelerated discovery of macromolecular
therapeutics such as peptides, proteins and polynucleotides. These macromolecules can be …

Genetic modification therapy is a promising therapeutic strategy for many diseases of the
lung intractable to other treatments. Lung gene therapy has been the subject of numerous …

Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary
diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are …

The concept of immunotherapy was in infancy when the first edition was written; since then,
major advances have been made, not only with several prominent clinical trials, but also …