Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Increasing evidence suggests that microglial activation is strongly linked to the initiation and
progression of Parkinson's disease. Cell-to-cell propagation of α-synuclein pathology is a …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Classically, the loss of vulnerable neuronal populations in neurodegenerative diseases was
considered to be the consequence of cell autonomous degeneration of neurons. However …

Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …

Toll-like receptors (TLRs) are pattern recognition receptors which mediate an inflammatory
response upon the detection of specific molecular patterns found on foreign organisms and …

Aims Parkinson's disease and related disorders are devastating neurodegenerative
pathologies. Since α‐synuclein was identified as a main component of Lewy bodies and …

Objective To develop a diagnostic model based on plasma-derived extracellular vesicle
(EV) subpopulations in Parkinson disease (PD) and atypical parkinsonism (AP), we applied …

Synucleinopathies are a group of progressive neurodegenerative diseases known for the
accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn) …