[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …
valuable method for identifying elderly people at risk for increased vulnerability, disease …
Role of the complement system in the tumor microenvironment
R Zhang, Q Liu, T Li, Q Liao, Y Zhao - Cancer Cell International, 2019 - Springer
The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to lithium in bipolar affective disorder: a genome-wide …
Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30 …
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30 …
Therapeutic mechanisms of lithium in bipolar disorder: recent advances and current understanding
Lithium is the most effective and well established treatment for bipolar disorder, and it has a
broad array of effects within cellular pathways. However, the specific processes through …
broad array of effects within cellular pathways. However, the specific processes through …
Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
S Chen, Y Tan, L Tian - Molecular Psychiatry, 2024 - nature.com
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of
both innate and adaptive immune components in psychotic disorders such as …
both innate and adaptive immune components in psychotic disorders such as …
Lithium in cancer therapy: friend or foe?
C Yang, B Zhu, M Zhan, ZC Hua - Cancers, 2023 - mdpi.com
Simple Summary Lithium has served as a mental stabilizer since the 20th century. Several
recent studies have demonstrated the antitumor effects of lithium. Lithium can also mitigate …
recent studies have demonstrated the antitumor effects of lithium. Lithium can also mitigate …
Microglial production of TNF-alpha is a key element of sustained fear memory
The proinflammatory cytokine productions in the brain are altered in a process of fear
memory formation, indicating a possibility that altered microglial function may contribute to …
memory formation, indicating a possibility that altered microglial function may contribute to …
Linking activation of microglia and peripheral monocytic cells to the pathophysiology of psychiatric disorders
A wide variety of studies have identified microglial activation in psychiatric disorders, such
as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but …
as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but …
From direct to indirect lithium targets: a comprehensive review of omics data
M Roux, A Dosseto - Metallomics, 2017 - academic.oup.com
Metal ions are critical to a wide range of biological processes. Among them, lithium (Li) has
been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet …
been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet …
Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia
Microglia have been suggested to be involved in the underlying mechanism of conditional
fear memory formation by regulating inflammatory cytokines. However, the mechanism …
fear memory formation by regulating inflammatory cytokines. However, the mechanism …