Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Biometal dyshomeostasis and toxic metal accumulation are common features in many
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and …

Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in
metal homeostasis and detoxification. While known for their high affinity for d10 metal ions …

Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly
expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth …

Zinc is an essential trace element that plays a vital role in maintaining many biological
processes and cellular homeostasis. Dysfunctional zinc signaling is associated with a …

Amyloid-β (Aβ) is believed to directly affect memory and learning in Alzheimer's disease
(AD). It is widely suggested that there is a relationship between Aβ 40 and Aβ 42 levels and …