Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

The influence of nutrition on clinical outcomes in children with cancer

RD Barr, MCG Stevens - Pediatric Blood & Cancer, 2020 - Wiley Online Library
Adequate and appropriate nutrition is essential for growth and development in children; all
put at risk in those with cancer. Overnutrition and undernutrition at diagnosis raise the risk of …

Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition

C Ling, CJ Versloot, MEA Kvissberg, G Hu, N Swain… - …, 2023 - thelancet.com
Background The intestine of children with severe malnutrition (SM) shows structural and
functional changes that are linked to increased infection and mortality. SM dysregulates the …

Metabolic phenotyping of malnutrition during the first 1000 days of life

J Mayneris-Perxachs, JR Swann - European Journal of Nutrition, 2019 - Springer
Nutritional restrictions during the first 1000 days of life can impair or delay the physical and
cognitive development of the individual and have long-term consequences for their health …

Malnutrition and the microbiome as modifiers of early neurodevelopment

EJL Coley, EY Hsiao - Trends in neurosciences, 2021 - cell.com
Malnutrition refers to a dearth, excess, or altered differential ratios of calories,
macronutrients, or micronutrients. Malnutrition, particularly during early life, is a pressing …

Inflammation: the driver of poor outcomes among children with severe acute malnutrition?

JP Sturgeon, JM Njunge, CD Bourke… - Nutrition …, 2023 - academic.oup.com
Severe acute malnutrition (SAM) is the most life-threatening form of undernutrition and
underlies at least 10% of all deaths among children younger than 5 years in low-income …

Current understanding of innate immune cell dysfunction in childhood undernutrition

CD Bourke, KDJ Jones, AJ Prendergast - Frontiers in immunology, 2019 - frontiersin.org
Undernutrition affects millions of children in low-and middle-income countries (LMIC) and
underlies almost half of all deaths among children under 5 years old. The growth deficits that …

[HTML][HTML] Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

JM Horcas-Nieto, CJ Versloot… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Hospitalized children with severe malnutrition face high mortality rates and often suffer from
hepatic and intestinal dysfunction, with negative impacts on their survival. New treatments …

[HTML][HTML] Intestinal epithelial digestive, transport, and barrier protein expression is increased in environmental enteric dysfunction

S Abtahi, A Sailer, JT Roland, X Haest… - Laboratory …, 2023 - Elsevier
Environmental enteric dysfunction (EED) is characterized by malabsorption and diarrhea
that result in irreversible deficits in physical and intellectual growth. We sought to define the …

[HTML][HTML] Environmental, metabolic, and inflammatory factors converge in the pathogenesis of moderate acute malnutrition in children: an observational cohort study

GT Patterson, D Manthi, F Osuna, A Muia… - The American Journal …, 2021 - ncbi.nlm.nih.gov
Acute malnutrition affects more than 50 million children worldwide. These children are at an
increased risk of morbidity and mortality from infectious disease. However, the pathogenesis …