Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI)

SG Mueller, MW Weiner, LJ Thal, RC Petersen… - Alzheimer's & …, 2005 - Elsevier
With the increasing life expectancy in developed countries, the incidence of Alzheimer's
disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over …

High‐field magnetic resonance imaging of brain iron: birth of a biomarker?

JF Schenck, EA Zimmerman - NMR in Biomedicine: An …, 2004 - Wiley Online Library
The brain has an unusually high concentration of iron, which is distributed in an unusual
pattern unlike that in any other organ. The physiological role of this iron and the reasons for …

Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis

RG Steen, RM Hamer, JA Lieberman - Neuropsychopharmacology, 2005 - nature.com
A systematic review of the literature identified 64 published English-language papers that
used proton (1 H) magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) …

Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia

C Zarow, HV Vinters, WG Ellis… - Annals of Neurology …, 2005 - Wiley Online Library
The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus is vulnerable
to both Alzheimer's disease (AD)‐type neurofibrillary degeneration and anoxia–ischemia …

Influence of comorbidities in idiopathic normal pressure hydrocephalus—research and clinical care. A report of the ISHCSF task force on comorbidities in INPH

J Malm, NR Graff-Radford, M Ishikawa… - Fluids and Barriers of …, 2013 - Springer
Idiopathic normal pressure hydrocephalus (INPH) is a syndrome of ventriculomegaly, gait
impairment, cognitive decline and incontinence that occurs in an elderly population prone to …

Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging

AA Maudsley, A Darkazanli, JR Alger… - NMR in …, 2006 - Wiley Online Library
Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires
specialized spatial and spectral data processing methods and benefits from the use of …

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

N Schuff, S Matsumoto, J Kmiecik, C Studholme… - Alzheimer's & …, 2009 - Elsevier
BACKGROUND: Our objectives were to compare the effects of subcortical ischemic vascular
dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to …

White matter changes compromise prefrontal cortex function in healthy elderly individuals

CW Nordahl, C Ranganath, AP Yonelinas… - Journal of cognitive …, 2006 - direct.mit.edu
Abstract Changes in memory function in elderly individuals are often attributed to
dysfunction of the prefrontal cortex (PFC). One mechanism for this dysfunction may be …

Blood pressure and dementia—a comprehensive review

SP Kennelly, BA Lawlor… - Therapeutic advances in …, 2009 - journals.sagepub.com
Alzheimer's disease (AD) and vascular dementia (VaD) are important causes of cognitive
decline in the elderly. As a result of an ageing population worldwide, the incidence of …

1H MR spectroscopy in common dementias

K Kantarci, RC Petersen, BF Boeve, DS Knopman… - Neurology, 2004 - AAN Enterprises
Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences
among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia …