This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The transcription factor Nrf2 (NF-E2-related factor 2) plays a vital role in maintaining cellular
homeostasis, especially upon the exposure of cells to chemical or oxidative stress, through …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …

There is a growing global concern about the health implications of xenobiotics, which have
harmful effects to both humans and wildlife. Among them, teleost fish are known as very …

Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees,
which is often found in foods such as onions and olive oil, and is also used in commercial …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

The Sixth Edition of this well-known text has been fully revised and updated to meet the
changing curricula of medicinal chemistry courses. Emphasis is on patient-focused …

The liver is the center for drug and xenobiotic metabolism, which is influenced most with
medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and …

Toxicity has been estimated to be responsible for the attrition of approximately one-third of
drug candidates and is a major contributor to the high cost of drug development, particularly …

This leading textbook in the field examines the mechanisms underlying toxicity, particularly
the events at the molecular level and the factors that determine and affect toxicity. The new …