The functionalisation of C–H bonds has been an enormous achievement in synthetic
methodology, enabling new retrosynthetic disconnections and affording simple synthetic …

The chemical activation of water would allow this earth-abundant resource to be transferred
into value-added compounds, and is a topic of keen interest in energy research,. Here, we …

Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry,
and ligand design for transition metals. However, state-of-the-art methods cannot be applied …

Hydrogen-atom transfer mediated by earth-abundant transition-metal hydrides (M-Hs) has
emerged as a powerful tool in organic synthesis. Current methods to generate M-Hs most …

Direct functionalization of C (sp3)–H bonds represents a pivotal objective in the realm of
synthetic chemistry. However, inherent chemical inertness coupled with low reactivity …

Metallaphotoredox cross-coupling is a well-established strategy for generating clinically
privileged aliphatic scaffolds via single-electron reactivity. Correspondingly, expanding …

The first-row transition-metal-catalyzed hydrogen atom transfer reaction has emerged as a
practical synthetic platform for alkene hydrofunctionalization with high chemo-and …

Detailed herein are our synthesis studies of longiborneol and related natural products. Our
overarching goals of utilizing a “camphor first” strategy enabled by skeletal remodeling of …

We have accomplished the total synthesis of sculponin U, a polycyclic C‐20‐oxygenated
kaurane diterpenoid featuring a 7, 20‐lactone‐hemiketal bridge, through a radical cascade …

Asymmetric hydrogenation of activated olefins using transition metal catalysis is a powerful
tool for the synthesis of complex molecules, but traditional metal catalysts have difficulty with …