Passive immunotherapy of viral infections:'super-antibodies' enter the fray

LM Walker, DR Burton - Nature Reviews Immunology, 2018 - nature.com
Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …

Nanotechnology for virus treatment

J Zhou, N Krishnan, Y Jiang, RH Fang, L Zhang - Nano Today, 2021 - Elsevier
The continued emergence of novel viruses poses a significant threat to global health.
Uncontrolled outbreaks can result in pandemics that have the potential to overburden our …

An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

ND Grubaugh, K Gangavarapu, J Quick, NL Matteson… - Genome biology, 2019 - Springer
How viruses evolve within hosts can dictate infection outcomes; however, reconstructing this
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …

Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics

P Gilchuk, RG Bombardi, JH Erasmus, Q Tan… - Nature biomedical …, 2020 - nature.com
The emergence and re-emergence of highly virulent viral pathogens with the potential to
cause a pandemic creates an urgent need for the accelerated discovery of antiviral …

Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets

IJ Kim, MP Tighe, MJ Clark, GD Gromowski… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV …

Current status of Zika vaccine development: Zika vaccines advance into clinical evaluation

ADT Barrett - npj Vaccines, 2018 - nature.com
Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in
Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV …

A combination of two human monoclonal antibodies prevents Zika virus escape mutations in non-human primates

JR Keeffe, KKA Van Rompay, PC Olsen, Q Wang… - Cell reports, 2018 - cell.com
Zika virus (ZIKV) causes severe neurologic complications and fetal aberrations. Vaccine
development is hindered by potential safety concerns due to antibody cross-reactivity with …

Animal models of Zika virus infection during pregnancy

EA Caine, BW Jagger, MS Diamond - Viruses, 2018 - mdpi.com
Zika virus (ZIKV) emerged suddenly in the Americas in 2015 and was associated with a
widespread outbreak of microcephaly and other severe congenital abnormalities in infants …

Maternal-fetal interplay in Zika virus infection and adverse perinatal outcomes

FME Teixeira, AJ Pietrobon, LM Oliveira… - Frontiers in …, 2020 - frontiersin.org
During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-
rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral …

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

DM Magnani, TF Rogers, NJ Maness… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of
fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a …