Many types of ion channel localize to cholesterol and sphingolipid‐enriched regions of the
plasma membrane known as lipid microdomains or 'rafts'. The precise physiological role of …

Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

A variety of ion channels, including members of all major ion channel families, have been
shown to be regulated by changes in the level of membrane cholesterol and partition into …

Epithelial Na+ channels (ENaCs) are members of a family of cation channels that function as
sensors of the extracellular environment. ENaCs are activated by specific proteases in the …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Exosomes are endosome-derived nanovesicles that are involved in cellular communication
and signaling. Exosomes are produced by epithelial cells and are found in biologic fluids …

The major membrane lipid regulators of ion channel function include cholesterol, one of the
main lipid components of the plasma membranes, phosphoinositides, a group of regulatory …

The mechanisms of regulation of ENaC are increasingly understood to be a complex
interplay of many different levels and systems. Proteolytic cleavage of α and γ subunits plays …