Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities

CM Laumont, AC Banville, M Gilardi, DP Hollern… - Nature Reviews …, 2022 - nature.com
Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity

CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

New-onset IgG autoantibodies in hospitalized patients with COVID-19

SE Chang, A Feng, W Meng, SA Apostolidis… - Nature …, 2021 - nature.com
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune
features and autoantibody production. Here we develop three protein arrays to measure IgG …

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

P Luo, Q Zhang, TY Zhong, JY Chen, JZ Zhang… - Military Medical …, 2022 - Springer
Background Sepsis involves life-threatening organ dysfunction and is caused by a
dysregulated host response to infection. No specific therapies against sepsis have been …

Interferon deficiency can lead to severe COVID

E Meffre, A Iwasaki - 2020 - nature.com
Interferon deficiency can lead to severe COVID Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Anti-cytokine autoantibodies: mechanistic insights and disease associations

A Cheng, SM Holland - Nature Reviews Immunology, 2024 - nature.com
Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …

Polysaccharides of mushroom Pleurotus spp.: New extraction techniques, biological activities and development of new technologies

JR Barbosa, MM dos Santos Freitas… - Carbohydrate …, 2020 - Elsevier
The biodiversity of mushrooms Pleurotus spp. is impressive due to its complexity and
diversity related to the composition of chemical structures such as polysaccharides …

Impaired B‐cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies

E Meffre, KC O'Connor - Immunological reviews, 2019 - Wiley Online Library
A role for B cells in autoimmune diseases is now clearly established both in mouse models
and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti …

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

EMN Ferré, MM Schmitt, MS Lionakis - Frontiers in pediatrics, 2021 - frontiersin.org
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known
as autoimmune polyglandular syndrome type-1 (APS-1), is a rare monogenic autoimmune …

Regulatory T cell development in the thymus

DL Owen, LE Sjaastad, MA Farrar - The Journal of Immunology, 2019 - journals.aai.org
Abstract Development of a comprehensive regulatory T (T reg) cell compartment in the
thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study …