[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology

Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

Antibody-dependent enhancement of severe dengue disease in humans

LC Katzelnick, L Gresh, ME Halloran, JC Mercado… - Science, 2017 - science.org
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

Zika virus pathogenesis and tissue tropism

JJ Miner, MS Diamond - Cell host & microbe, 2017 - cell.com
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental
studies had been published prior to 2016. The recent spread of ZIKV to countries in the …

Adaptive immune responses to primary and secondary dengue virus infections

AL St. John, APS Rathore - Nature Reviews Immunology, 2019 - nature.com
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …

Structures of the Zika virus envelope protein and its complex with a flavivirus broadly protective antibody

L Dai, J Song, X Lu, YQ Deng, AM Musyoki, H Cheng… - Cell host & …, 2016 - cell.com
Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The
flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major …

Structural basis of potent Zika–dengue virus antibody cross-neutralization

G Barba-Spaeth, W Dejnirattisai, A Rouvinski… - Nature, 2016 - nature.com
Zika virus is a member of the Flavivirus genus that had not been associated with severe
disease in humans until the recent outbreaks, when it was linked to microcephaly in …

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

W Dejnirattisai, P Supasa, W Wongwiwat… - Nature …, 2016 - nature.com
Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relatively mild disease.
The recent explosive outbreak of ZIKV in South America has led to widespread concern, with …

Rapid development of a DNA vaccine for Zika virus

KA Dowd, SY Ko, KM Morabito, ES Yang, RS Pelc… - Science, 2016 - science.org
Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive
outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal …

Structural basis of Zika virus-specific antibody protection

H Zhao, E Fernandez, KA Dowd, SD Speer, DJ Platt… - Cell, 2016 - cell.com
Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem
because of its ability to cause severe congenital disease. Here, we developed six mouse …