Despite the recent advances in controlling some viral pathogens, most viral infections still
lack specific treatment. Indeed, the need for effective therapeutic strategies to combat 'old' …

Herpes simplex virus type I (HSV-1) is the causative agent of several pathologies ranging in
severity from the common cold sore to life-threatening encephalitic infection. During …

Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it
is. This is based on the observation that, although there is immense genomic variation, every …

Translocation of viral double-stranded DNA (dsDNA) into the icosahedral prohead shell is
catalyzed by TerL, a motor protein that has ATPase, endonuclease, and translocase …

Human cytomegalovirus (HCMV) is responsible for life-threatening infections in
immunocompromised individuals and can cause serious congenital malformations …

Human herpesviruses are large double-stranded DNA viruses belonging to the
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …

Infection with cytomegalovirus is prevalent in immunosuppressed patients. In solid organ
transplant and hematopoietic stem cell transplant recipients, cytomegalovirus infection is …

Large dsDNA bacteriophages and herpesviruses encode a powerful ATP-driven DNA-
translocating machine that encapsidates a viral genome into a preformed capsid shell or …

The genome packaging motor of bacteriophages and herpesviruses is built by two
terminase subunits, known as large (TerL) and small (TerS), both essential for viral genome …

Cleavage of human cytomegalovirus (HCMV) genomes as well as their packaging into
capsids is an enzymatic process mediated by viral proteins and therefore a promising target …