Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Hypertension in diabetes: an update of basic mechanisms and clinical disease

G Jia, JR Sowers - Hypertension, 2021 - Am Heart Assoc
Epidemiological studies have documented that insulin resistance and diabetes not only
constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness …

Adolescent obesity: diet quality, psychosocial health, and cardiometabolic risk factors

LD Ruiz, ML Zuelch, SM Dimitratos, RE Scherr - Nutrients, 2019 - mdpi.com
Obesity is a multifaceted chronic condition with several contributing causes, including
biological risk factors, socioeconomic status, health literacy, and numerous environmental …

The adolescent with obesity: what perspectives for treatment?

A Nicolucci, C Maffeis - Italian journal of pediatrics, 2022 - Springer
The dramatic increase in overweight and obesity among children and adolescents has
become a major public health problem. Obesity in children and young adults is associated …

Cardiometabolic risk in obese children

ST Chung, AU Onuzuruike… - Annals of the New York …, 2018 - Wiley Online Library
Obesity in childhood remains a significant and prevalent public health concern. Excess
adiposity in youth is a marker of increased cardiometabolic risk (CMR) in adolescents and …

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Cellular mechanisms underlying obesity-induced arterial stiffness

AR Aroor, G Jia, JR Sowers - American Journal of …, 2018 - journals.physiology.org
Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

Effects of arterial stiffness and carotid intima-media thickness progression on the risk of overweight/obesity and elevated blood pressure/hypertension: a cross-lagged …

AO Agbaje, AR Barker, TP Tuomainen - Hypertension, 2022 - Am Heart Assoc
We examined the temporal longitudinal associations of carotid-femoral pulse wave velocity
(cfPWV), a measure of arterial stiffness, and carotid intima-media thickness (cIMT) with the …

Cumulative muscle mass and blood pressure but not fat mass drives arterial stiffness and carotid intima-media thickness progression in the young population and is …

AO Agbaje, AR Barker, TP Tuomainen - Hypertension Research, 2023 - nature.com
We examined the longitudinal associations of fat mass, lean mass, and blood pressure (BP)
from childhood through young adulthood with changes in carotid-femoral pulse wave …

Killing me unsoftly: causes and mechanisms of arterial stiffness

AN Lyle, U Raaz - Arteriosclerosis, thrombosis, and vascular …, 2017 - Am Heart Assoc
The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …