Insights into active targeting of nanoparticles in drug delivery: advances in clinical studies and design considerations for cancer nanomedicine

AK Pearce, RK O'Reilly - Bioconjugate chemistry, 2019 - ACS Publications
Nanomedicine is a promising strategy for improving clinical outcomes for cancer therapies,
by improving drug efficacy through enhanced delivery to disease sites. It is of importance for …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and …

LD Blackman, S Varlas, MC Arno, ZH Houston… - ACS central …, 2018 - ACS Publications
Covalent PEGylation of biologics has been widely employed to reduce immunogenicity,
while improving stability and half-life in vivo. This approach requires covalent protein …

Recent advances in targeted nanomedicine as promising antitumor therapeutics

S Hejmady, R Pradhan, A Alexander, M Agrawal… - Drug discovery today, 2020 - Elsevier
Highlights•Nanocarriers with the ability to target tumors are being increasingly explored.•
Nanomedicine aid in maintaining a balance between efficacy and toxicity.•Recent advances …

Protective effects of dexazoxane on rat ferroptosis in doxorubicin-induced cardiomyopathy through regulating HMGB1

H Zhang, Z Wang, Z Liu, K Du, X Lu - Frontiers in cardiovascular …, 2021 - frontiersin.org
Dexrazoxane (DXZ) reduces cytotoxicity caused by Doxorubicin (DOX). However, the
mechanism of DXZ in ferroptosis and cardiomyopathy remains unclear. This research …

Synthesis and functionalization of hyperbranched polymers for targeted drug delivery

A Kavand, N Anton, T Vandamme, CA Serra… - Journal of Controlled …, 2020 - Elsevier
Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as
optical, electronic and magnetic materials, coatings, additives, supramolecular chemistry …

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

M Ashrafizadeh, Z Ahmadi, N Mohamadi… - International journal of …, 2020 - Elsevier
Paclitaxel (PTX) and docetaxel (DTX) are key members of taxanes with high anti-tumor
activity against various cancer cells. These chemotherapeutic agents suffer from a number of …

Targeting prostate cancer: prostate‐specific membrane antigen based diagnosis and therapy

T Wüstemann, U Haberkorn, J Babich… - Medicinal research …, 2019 - Wiley Online Library
The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic
strategies. Prostate tumors specifically express the prostate‐specific membrane antigen …

Targeted delivery to tumors: multidirectional strategies to improve treatment efficiency

OM Kutova, EL Guryev, EA Sokolova, R Alzeibak… - Cancers, 2019 - mdpi.com
Malignant tumors are characterized by structural and molecular peculiarities providing a
possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and …

Theranostic designs of biomaterials for precision medicine in cancer therapy

H Kim, G Kwak, K Kim, HY Yoon, IC Kwon - Biomaterials, 2019 - Elsevier
Theranostic biomaterials have been creating great new opportunities in developing
precision medicine in cancer treatment. Moreover, there exist up-coming potentials to find a …