Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma
Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the
kidney, and is characterized histologically by large intracellular lipid deposits. These …
kidney, and is characterized histologically by large intracellular lipid deposits. These …
[HTML][HTML] Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma
The molecular mechanisms whereby transforming growth factor-β (TGF-β) promotes clear
cell renal cell carcinoma (ccRCC) progression is elusive. The cell membrane bound TGF-β …
cell renal cell carcinoma (ccRCC) progression is elusive. The cell membrane bound TGF-β …
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell …
S Chintala, T Najrana, K Toth, S Cao, FA Durrani, R Pili… - BMC cancer, 2012 - Springer
Background Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the
cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene …
cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene …
VHL L169P variant does not Alter cellular hypoxia tension in clear cell renal cell carcinoma
J Hu, DJ Smith, L Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
In the current era of tumor genome sequencing, single amino acid missense variants in the
von Hippel–Lindau (VHL) tumor suppressor gene are frequently identified in clear cell renal …
von Hippel–Lindau (VHL) tumor suppressor gene are frequently identified in clear cell renal …
[HTML][HTML] TGF-β inducible epithelial-to-mesenchymal transition in renal cell carcinoma
S Tretbar, P Krausbeck, A Müller, M Friedrich… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Epithelial-to-mesenchymal transition (EMT) is a crucial step in cancer progression and the
number one reason for poor prognosis and worse overall survival of patients. Although this …
number one reason for poor prognosis and worse overall survival of patients. Although this …
Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma
K Tóth, S Chintala, YM Rustum - Applied Immunohistochemistry & …, 2014 - journals.lww.com
The extensive lipid accumulation occurring in clear-cell renal cell carcinoma (ccRCC) results
in a clear-cell cytoplasm. Hypoxia-inducible factor α (HIF-α) is constitutively expressed in …
in a clear-cell cytoplasm. Hypoxia-inducible factor α (HIF-α) is constitutively expressed in …
Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma
SS Damjanovic, BB Ilic, BBB Cokic, JA Antic… - … and molecular pathology, 2016 - Elsevier
Abstract Alterations in von Hippel-Lindau gene (VHL) do not determine deregulation of
hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on …
hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on …
Tubulocystic renal cell carcinoma: is there a rational reason for targeted therapy using angiogenic inhibition? Analysis of seven cases
P Steiner, M Hora, J Stehlik, P Martinek, T Vanecek… - Virchows Archiv, 2013 - Springer
Generally, patients with renal cell carcinoma (RCC) are viewed as potential candidates for
antiangiogenic targeted therapy. Tubulocystic RCC (TCRC) is a recently described entity …
antiangiogenic targeted therapy. Tubulocystic RCC (TCRC) is a recently described entity …
[HTML][HTML] VHL dependent expression of REDD1 and PDK3 proteins in clear-cell renal cell carcinoma
BB Ilic, JA Antic, JZ Bankovic, IT Milicevic… - Journal of Medical …, 2018 - ncbi.nlm.nih.gov
Background Sporadic clear-cell renal cell carcinoma (ccRCC) is associated with mutations
in the VHL gene, upregulated mammalian target of rapamycin (mTOR) activity and glycolytic …
in the VHL gene, upregulated mammalian target of rapamycin (mTOR) activity and glycolytic …
Próteintjáning nýrnafrumukrabbameina. Samanburður á próteintjáningu nýrnafrumukrabbameina af tærfrumugerð og eðlilegs nýrnavefjar
SD Tómasdóttir - skemman.is
Nýrnakrabbamein greinist í 2-3% tilfella allra illkynja greininga í fullorðnum einstaklingum á
heimsvísu og er banvænasta krabbameinið í þvagfærum. Algengasta nýrnakrabbameinið er …
heimsvísu og er banvænasta krabbameinið í þvagfærum. Algengasta nýrnakrabbameinið er …