NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future

S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment

SM Sousa, CPR Xavier… - Current Topics in …, 2023 - ingentaconnect.com
Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …

Cigarette smoking, by accelerating the cell cycle, promotes the progression of non-small cell lung cancer through an HIF-1α-METTL3-m6A/CDK2AP2 axis

Y Yang, C Cheng, B He, X Du, J Liu, H Xia… - Journal of hazardous …, 2023 - Elsevier
Cigarette smoking killed about 8 million people every year and promoted non-small cell lung
cancer (NSCLC). We investigated the molecular mechanism of smoking-promoted NSCLC …

Tissue‐resident CXCR4+ macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression

Z Liao, L Ye, T Li, X Jin, X Lin, Q Fei… - … Journal of Cancer, 2023 - Wiley Online Library
Macrophage is an essential part of the tumor immune microenvironment of pancreatic ductal
adenocarcinoma. In our study, we explored the CXCR4+ macrophages subset on its …

Deciphering the effects and mechanisms of Yi-Fei-San-Jie-pill on non-small cell lung cancer with integrating network target analysis and experimental validation

H Yang, Q Guo, J Wu, L Zhong, L Sun, W Liu… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung cancer (NSCLC), which accounts for 85% of lung cancer cases, calls for
better therapy. Yi-Fei-San-Jie-pill (YFSJ), a well-applicated traditional Chinese medicine …

[HTML][HTML] Neuroendocrine transformation from EGFR/ALK-wild type or TKI-naïve non-small cell lung cancer: An under-recognized phenomenon

X Chu, Y Xu, Y Li, Y Zhou, L Chu, X Yang, J Ni, Y Li… - Lung Cancer, 2022 - Elsevier
Introduction Neuroendocrine transformation (NET) is a resistance mechanism for epidermal
growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors …

[HTML][HTML] Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model

V Madka, A De La Cruz, G Pathuri… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) incidence is rising globally. Hence, preventing this disease is a
high priority. With this aim, we determined the CRC prevention potential of the TRAIL …

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

X Liu, J Zhang, W Sun, J Cao… - Chronic Diseases and …, 2024 - Wiley Online Library
Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small
cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced …

NKp44-derived peptide used in combination stimulates antineoplastic efficacy of targeted therapeutic drugs

M Iraqi, P Bolel, R Sarkar, B Bhattacharya… - International Journal of …, 2022 - mdpi.com
Lung cancer cells in the tumor microenvironment facilitate immune evasion that leads to
failure of conventional chemotherapies, despite provisionally decided on the genetic …

CYP2C9 MEDIATES THE HERB-DRUG INTERACTION OF CURCUMIN WITH NAPROXEN IN RATS.

Y QIU, S HUANG, M ZHU - Acta Poloniae Pharmaceutica, 2023 - search.ebscohost.com
Both curcumin and naproxen have pain relief activity, making it possible to co-administrate
these drugs in the same prescription. This study aimed to assess the potential …