Although voltage-activated Ca2+ channels are a common feature in excitable cells, their
expression in cancer tissue is less understood. T-type Ca2+ channels are particularly …

While L-type voltage-dependent calcium channels have long been considered the
predominant source of calcium for myogenic constriction, recent studies of both cerebral and …

Although dihydropyridines are widely used for the treatment of vasospasm, their
effectiveness is questionable, suggesting that other voltage-dependent calcium channels …

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …

Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous
system, but little is known about when or how their unique properties and cellular roles …

Voltage-gated calcium channels (VGCCs) represent a key link between electrical signals
and non-electrical processes, such as contraction, secretion and transcription. Evolved to …

Background Previous studies have shown that increased excitability of capsaicin-sensitive
DRG neurons and thermal hyperalgesia in rats with short-term (2–4 weeks) streptozotocin …

T-type (Ca v 3) channels are categorized as calcium channels, but invertebrate ones can be
highly sodium-selective channels. We illustrate that the snail LCa v 3 T-type channel …

Ca v 3 T-type channels are low-voltage-gated channels with rapid kinetics that are classified
among the calcium-selective Ca v 1 and Ca v 2 type channels. Here, we outline the …

The α1, β, and α2δ subunits of voltage-gated calcium channels emerged before animals,
and are present in all animal genomes, including those that lack nervous systems and …