Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

Aging-induced pro-inflammatory phenotypic alterations of the cerebral vasculature critically
contribute to the pathogenesis of vascular cognitive impairment. Cellular senescence is a …

There has been an increasing appreciation of the role of vascular contributions to cognitive
impairment and dementia (VCID) associated with old age. Strong preclinical and …

Androgenetic alopecia (AGA) is the most common type of hair loss and features progressive
miniaturization of hair follicles. Generally, the occurrence of AGA has long been thought to …

Let alone calorie restriction, life span extension in higher organisms has proven to be
difficult to achieve using simple drugs. Previous studies have shown that the polyamine …

Abstract Purpose of Review We review cell senescence in the context of age-related bone
loss by broadly discussing aging mechanisms in bone, currently known inducers and …

Aging remains the most pervasive risk factor for a wide range of chronic diseases that afflict
modern societies. In the United States alone, incidence of age-related diseases (eg …