Molecular dynamics simulations are an invaluable tool to characterize the dynamic motions
of proteins in atomistic detail. However, the accuracy of models derived from simulations …

Allergens are substances that cause abnormal immune responses and can originate from
various sources. IgE-mediated allergies are one of the most common and severe types of …

Antigen uptake and processing of exogenous proteins is critical for adaptive immunity,
particularly for T helper cell activation. Proteins undergo distinct proteolytic processing in …

Protein flexibility remains a major challenge in library docking because of difficulties in
sampling conformational ensembles with accurate probabilities. Here, we use the model …

The family of profilin allergens is a common class of proteins found in plants, viruses and
various eukaryotes including mammals. Profilins are characterized by an evolutionary …

Nanomaterials have found extensive interest in the development of novel vaccines, as
adjuvants and/or carriers in vaccination platforms. Conjugation of protein antigens at the …

Susceptibility to endosomal degradation is a decisive contribution to a protein's
immunogenicity. It is assumed that the processing kinetics of structured proteins are …