Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum
parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a …

Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from
the Asteraceae family. They exert a broad variety of different biological activities. This review …

Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on
their alkylating capabilities, which underlie their therapeutic potential. These compounds are …

Leukemia is a heterogeneous group of hematological malignancies distinguished by
differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor …

α-Methylene-γ-and δ-lactones, as well as α-methylene-γ-and δ-lactams, are plant-derived
compounds often used in traditional medicine for the treatment of inflammatory diseases. In …

Sesquiterpene lactones (SLs) are plant-derived compounds that are abundant in plants of
the Asteraceae family and posses a broad spectrum of biological activities, ranging from anti …

In this study, we characterized nuclear factor κB (NF-κB) subunit DNA binding in chronic
lymphocytic leukemia (CLL) samples and demonstrated heterogeneity in basal and …

Parthenolide (PTL), a major active sesquiterpene lactone from the herbal plant Tanacetum
parthenium, has been applied in traditional Chinese medicine for centuries. Although PTL …