Updates in SJS/TEN: collaboration, innovation, and community

ME Marks, RK Botta, R Abe, TM Beachkofsky… - Frontiers in …, 2023 - frontiersin.org
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-
induced disease, with a mortality rate of 15–20%, that engages the expertise of multiple …

New insights into the diagnosis and management of Stevens–Johnson syndrome and toxic epidermal necrolysis

Y Saito, R Abe - Current Opinion in Allergy and Clinical …, 2023 - journals.lww.com
The pathogenesis of SJS/TEN remains unclear and effective therapeutic agents have not yet
been established. As the involvement of innate immunity, such as monocytes and …

Spatial proteomics identifies JAKi as treatment for a lethal skin disease

TM Nordmann, H Anderton, A Hasegawa, L Schweizer… - Nature, 2024 - nature.com
Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common
medications and is an emerging public health issue,–. Patients with TEN undergo severe …

Management of adult patients with drug reaction with eosinophilia and systemic symptoms: a Delphi-based international consensus

MC Brüggen, S Walsh, MM Ameri… - JAMA …, 2024 - jamanetwork.com
Importance Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but
potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international …

Inhibition of tumor necrosis factor improves conventional steroid therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis in a cohort of patients

S Ao, X Gao, J Zhan, L Ai, M Li, H Su, X Tang… - Journal of the American …, 2022 - Elsevier
Background Systemic steroid therapies for Stevens-Johnson syndrome (SJS)/toxic
epidermal necrolysis (TEN) have been challenged because of their limited benefits. Whether …

Severe cutaneous adverse reactions

SI Hung, M Mockenhaupt, KG Blumenthal… - Nature Reviews …, 2024 - nature.com
Severe cutaneous adverse reactions (SCARs), which include Stevens–Johnson syndrome
and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (also …

Recent progress in Stevens–Johnson syndrome/toxic epidermal necrolysis: diagnostic criteria, pathogenesis and treatment

N Hama, S Aoki, CB Chen, A Hasegawa… - British Journal of …, 2025 - academic.oup.com
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a severe
spectrum of rare mucocutaneous reactions that are primarily drug-induced and …

Intravenous immunoglobulins, cyclosporine, and best supportive care in epidermal necrolysis: diverse effects on systemic inflammation

V Schmidt, S Lalevée, S Traidl, M Ameri, R Ziadlou… - Allergy, 2023 - Wiley Online Library
Abstract Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis
(TEN) are rare but potentially life‐threatening cutaneous adverse reactions. There is still no …

Stevens-Johnson syndrome and toxic epidermal necrolysis associated with immune checkpoint inhibitors: a systematic review

J Zhou, CP Wang, J Li, HL Zhang, CX He - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
rare yet life-threatening adverse events associated with immune checkpoint inhibitors (ICIs) …

Acute generalized exanthematous pustulosis: European expert consensus for diagnosis and management

F Tetart, S Walsh, B Milpied, K Gaspar… - Journal of the …, 2024 - Wiley Online Library
Acute generalized exanthematous pustulosis (AGEP) is a rare, usually drug‐induced, acute
pustular rash. Despite the lack of strong data supporting the effectiveness of topical or …