Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer

TF Stoop, RT Theijse, LWF Seelen… - Nature Reviews …, 2024 - nature.com
Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …

Surgical considerations for neoadjuvant therapy for pancreatic adenocarcinoma

AJ Jain, JE Maxwell, MHG Katz, RA Snyder - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a morbid malignancy with
discouraging survival rates. Enthusiasm for pre-operative therapy (chemotherapy, radiation …

Early recurrence after resection of locally advanced pancreatic cancer following induction therapy: an international multicenter study

LWF Seelen, AF Van Oosten, LJH Brada… - Annals of …, 2023 - journals.lww.com
Objective: To establish an evidence-based cutoff and predictors for early recurrence in
patients with resected locally advanced pancreatic cancer (LAPC). Background: It is unclear …

Minimum and optimal CA19-9 response after two months induction chemotherapy in patients with locally advanced pancreatic cancer: a nationwide multicenter study

LWF Seelen, D Doppenberg, TF Stoop… - Annals of …, 2024 - journals.lww.com
Objective: This nationwide multicenter study aimed to define clinically relevant thresholds of
relative serum CA19-9 response after 2 months of induction chemotherapy in patients with …

Currently debated topics on surgical treatment of pancreatic ductal adenocarcinoma: a narrative review on surgical treatment of borderline resectable, locally …

S Pedrazzoli - Journal of Clinical Medicine, 2023 - mdpi.com
Background: Previously considered inoperable patients (borderline resectable, locally
advanced, synchronous oligometastatic or metachronous pancreatic adenocarcinoma …

Role for neoadjuvant systemic therapy for potentially resectable pancreatic cancer

BG Smaglo - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is one of the deadliest cancers. It can only be cured by
surgery, and most people with pancreatic cancer are diagnosed when the cancer is too far …

Elevated CA 19-9 is associated with worse survival in patients with resected ampullary adenocarcinoma

A Boyev, LR Prakash, YJ Chiang, TE Newhook… - Surgical Oncology, 2023 - Elsevier
Background The prognostic utility of Carbohydrate Antigen 19-9 (CA 19-9) and
Carcinoembryonic Antigen (CEA) in ampullary adenocarcinoma is unclear. We sought to …

Tumor size reduction and serum carbohydrate antigen 19-9 kinetics after neoadjuvant FOLFIRINOX in patients with pancreatic ductal adenocarcinoma

M Servin-Rojas, ZV Fong, C Fernandez-Del Castillo… - Surgery, 2024 - Elsevier
Background Changes in tumor size and serum carbohydrate antigen 19-9 are commonly
reported markers used to assess response to neoadjuvant therapy in pancreatic ductal …

Pathological Complete Response in Patients With Resected Pancreatic Adenocarcinoma After Preoperative Chemotherapy

TF Stoop, A Oba, YHA Wu, LE Beaty… - JAMA Network …, 2024 - jamanetwork.com
Importance Preoperative chemo (radio) therapy is increasingly used in patients with
localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) in a …

In neoadjuvant FOLFIRINOX chemotherapy for pancreatic ductal adenocarcinoma, which response is the more reliable indicator for prognosis, radiologic or …

WG Yun, Y Han, YJ Cho, HS Jung, M Lee… - Annals of Surgical …, 2024 - Springer
Background In this era of increasing neoadjuvant chemotherapy, methods for evaluating
responses to neoadjuvant chemotherapy are still diverse among institutions. Additionally …