The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

The complement system is involved in the pathogenesis of several ocular diseases,
providing a rationale for the investigation of complement-targeting therapeutics for these …

Graft-versus-host disease (GVHD)–associated dry eye disease is characterized by extensive
inflammatory destruction in the ocular surface and causes unbearable pain and visual …

Virus infection modulates both host immunity and host genomic stability. Poly (ADP-ribose)
polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Since the last century, advances in healthcare, housing, and education have led to an
increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related …

Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after
allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other …

Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding
immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss …

Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to
environmental threats. The abundant corneal nerves are interspersed with epithelial cells in …

We report a rapid reduction in blink reflexes during in vivo ocular Pseudomonas aeruginosa
infection, which is commonly attributed and indicative of functional neuronal damage …