tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

The vast majority of proteins are believed to have one specific function. Throughout the
course of evolution, however, some proteins have acquired additional functions to meet the …

The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

▪ Abstract Ubiquitous in eukaryotic cells, the La protein associates with the 3′ termini of
many newly synthesized small RNAs. RNAs bound by the La protein include all nascent …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

The RNA binding proteome (RBP ome) was previously investigated using UV crosslinking
and purification of poly (A)‐associated proteins. However, most cellular transcripts are not …

Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis
employs a specialized RNA polymerase that generates initial transcripts that must be …