The quest for novel methods to mature human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) for cardiac regeneration, modelling and drug testing has …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …

Giant modular sarcomeric proteins such as titin have come under increasing scrutiny for
their contributions to diseases such as skeletal and cardiac myopathies. Many variants in …

In contracting striated muscle titin acts as a spring in parallel with the array of myosin motors
in each half-sarcomere and could prevent the intrinsic instability of thousands of serially …