This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

In neurons, but also in all other cells the complex proteostasis network is monitored and
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …

Abstract Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-
chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 …

BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle
but can also be found in the brain and in the peripheral nervous system. BAG3 functions in …

Acute leukemias are genetic diseases caused by translocations or mutations, which
dysregulate hematopoiesis towards malignant transformation. However, the molecular mode …

BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its
BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and …

A multistep model has been proposed of disease progression starting in monoclonal
gammopathy of undetermined significance continuing through multiple myeloma, sometimes …

Background BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70,
which helps, through the binding to the ATPase domain, the ADP release from the …

WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during
embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the most …