Activins and inhibins: roles in development, physiology, and disease

M Namwanje, CW Brown - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion
and erythropoiesis, the TGF-β family members activin and inhibin have been shown to …

Inhibin at 90: from discovery to clinical application, a historical review

Y Makanji, J Zhu, R Mishra, C Holmquist… - Endocrine …, 2014 - academic.oup.com
When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic
hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years …

FSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration

YJ Liu, JP Li, Y Zhang, MJ Nie, YH Zhang… - OncoTargets and …, 2021 - Taylor & Francis
Purpose Follistatin-related gene 3 (FSTL3), an established oncogene, can modulate target
gene expression via members of the transforming growth factor β (TGF-β) superfamily. The …

New insights into the mechanisms of activin action and inhibition

KL Walton, Y Makanji, CA Harrison - Molecular and cellular endocrinology, 2012 - Elsevier
Like other members of the transforming growth factor-β (TGF-β) superfamily, activins are
synthesised as precursor molecules comprising an N-terminal prodomain and C-terminal …

IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: An in vivo and in vitro study

G Tossetta, F Paolinelli, C Avellini, E Salvolini… - Placenta, 2014 - Elsevier
Introduction Chorioamnionitis is a gestational pathological condition characterized by acute
inflammation of the amniochorionic membranes and placentas leading to high …

Activin-A and myostatin response and steroid regulation in human myometrium: disruption of their signalling in uterine fibroid

P Ciarmela, E Bloise, PC Gray… - The Journal of …, 2011 - academic.oup.com
Context: Investigation of activin-A (A) and myostatin (M) in human myometrium (HM) and
leiomyoma (HL) will explain their involvement in human myometrial pathophysiology …

Activins and related proteins in the establishment of pregnancy

P Florio, M Gabbanini, LE Borges, L Bonaccorsi… - Reproductive …, 2010 - Springer
Activin A and related proteins (inhibins, follistatin [FS], follistatin-related gene [FLRG],
endometrial bleeding associated factors [ebaf]) are involved in the complex mechanisms …

Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis

FM Reis, S Luisi, MS Abrão, ALL Rocha… - Human …, 2012 - academic.oup.com
BACKGROUND Activin A is a growth factor, produced by the endometrium, whose actions
are modulated by the binding protein follistatin. Both proteins are detectable in the …

Differential expression of follistatin and FLRG in human breast proliferative disorders

E Bloise, HL Couto, L Massai, P Ciarmela… - BMC cancer, 2009 - Springer
Background Activins are growth factors acting on cell growth and differentiation. Activins are
expressed in high grade breast tumors and they display an antiproliferative effect inducing …

[HTML][HTML] Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination

P Florio, L Bruni, L Galleri, FM Reis, LE Borges… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To measure activin A concentrations in uterine washing fluid collected from
women with couple infertility undergoing intrauterine insemination (IUI). DESIGN …