▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …

1. Simultaneous whole‐cell recordings in a rat brain slice preparation are described from
presynaptic terminals (calyces of Held) and postsynaptic somata which form an axosomatic …

Large-conductance Ca2+-activated K+ channels (BK, also called Maxi-K or Slo channels)
are widespread in the vertebrate nervous system, but their functional roles in synaptic …

The primary function of the presynaptic nerve terminal is to release transmitter quanta and
thus activate the postsynaptic target cell. In almost every step leading to the release of …

Large conductance calcium‐and voltage‐activated potassium channels (BK channels)
activate in response to calcium influx during action potentials and contribute to the spike …

The understanding of neurotransmitter release at vertebrate synapses has been hampered
by the paucity of preparations in which presynaptic ionic currents and postsynaptic …

Neurotransmitter release during action potentials is thought to require transient, localized
[Ca 2+] i as high as hundreds of micromolar near presynaptic release sites. Most …

Paired-pulse facilitation (PPF) is a form of short-term, activity-dependent synaptic plasticity
common to most chemically transmitting synapses, manifested as an enhancement in the …

1. In a model synaptic system, the excitatory neuromuscular junction of the freshwater
crayfish, the nerve terminals possess synapses that vary in structural complexity, with …